PUBLICATIONs
247. “Engineering gene therapy across anatomical, biological and spatiotemporal barriers in high-grade gliomas”
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L.D.D Filippo, J.L. Duarte, G.A. de Paula, Z. Tian, A.C.L. de Almeida, Catarina Martins, Diana Peixoto, J. H. Azambuja, S. Yerneni1*, M. Chorilli* and João Conde*
246. “Pan-cancer analysis of fibroblasts and macrophages defines a prognostic stromal-immune axis in breast cancer”
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B. Xiao, L. Zhou, J. Yao, X. Tang, C. Yin, B. Yang, F. Zhao, Y. Zhou, J. Kuang, W. Jin, V. Balan, R. Mall, A. K. Barui, M. S., S. Liu, Y. Pan, João Conde and Z. Jiang.
245. “AI-driven multitarget drug design for overcoming therapeutic resistance in precision oncology”
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Z. Xu, Y. Li, F. Zhao, Y. Zhou, J. Kuang, D. Zhao, W. Li, C. Liu*, João Conde* and S. Liu*
244. “Global, regional, and national burden of smoking tobacco use and attributable disease in 204 countries and territories, 1990–2023: a systematic analysis from the Global Burden of Disease Study 2023”
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João Conde & GBD Collaborators - Global Burden of Disease (GBD) Consortium
243. “Drug-tolerant persister states as a clinically actionable origin of cancer therapy failure”
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242. “Global, regional, and national burden of soft tissue sarcomas and other extraosseous sarcomas, 1990-2023 with forecasts to 2050: a systematic analysis for the Global Burden of Disease Study 2023”
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João Conde & GBD Collaborators - Global Burden of Disease (GBD) Consortium
241. “WNK3 activates nuclear accumulation of GLI1 and recruits immunosuppressive CXCR2+ PMN-MDSCs to reduce CD8+ T cell cytotoxicity and promote colorectal tumorigenesis”
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J. Kuang, Y. Zhou, F. Zhao, C. Lin, Z. Qin, Q. Jiang, H. Deng, X. Guo, Q. Zhang, João Conde*, K. Zhu*, M. Tian*, P. Zhao* and J. Li*
240. “A Sprayable Sodium/Tannic Acid-Lipoic acid Hydrogel with Immunomodulatory and Pro-Adhesive Properties for Enhanced Burn Wound Regeneration”
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239. “Global, regional, and national burden of lung cancer and associated risk factors, 1990–2023, with forecasts to 2050: a systematic analysis for the Global Burden of Disease Study 2023”
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João Conde & GBD Collaborators - Global Burden of Disease (GBD) Consortium
238. “miRNA signature variability across multiple biological models exposes subtype and 3D compactness as dominant barriers to miR nanodelivery”
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Jhenifer Oliveira, Mariana Pereira, M. Soares, R. Murphy, A.R. Grosso, Bárbara B. Mendes and João Conde*
237. “Global, regional, and national burden of malignant neoplasm of bone and articular cartilage from 1990 to 2023 and forecasts to 2050: a systematic analysis for the Global Burden of Disease Study 2023”
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João Conde & GBD Collaborators - Global Burden of Disease (GBD) Consortium
236. “pH-triggered gold-PNA nanoclusters reverse miR-155-driven radioresistance in breast cancer”
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Y. Jiang, Y. Zhang, L. Zhou, H. Yang, H. Gao, W. Hai, C. Zhang, J. Yao, R. Mall, João Conde*, S. Li*, B. Li* and M. Zhang*
235. “Cancer survivorship burden is rising worldwide with widening inequalities”
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João Conde & GBD Collaborators - Global Burden of Disease (GBD) Consortium
234. “Spatiotemporal thermal gating of a soft nanocomposite enables on demand in situ tumour RNA interference with non-ablative hyperthermia”
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Catarina F. Martins, Diana Peixoto, C. García-Astrain, T. Pinheiro, Bárbara B. Mendes, Jhenifer Oliveira, L.M. Liz-Marzán and João Conde*
233. “Global, regional, and national burden of colon and rectum cancer from 1990 to 2023, with forecasts to 2050: a systematic analysis for the Global Burden of Disease Study 2023”
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João Conde & GBD Collaborators - Global Burden of Disease (GBD) Consortium
232. “Engineering hybrid cell membrane nanovesicles and biomimetic nanoparticles for cancer diagnosis and therapy”
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Diana Peixoto, F. Veiga, A. Concheiro, A.C. Paiva-Santos, C. Alvarez-Lorenzo* and João Conde*
231. “Global, regional, and national burden of stomach cancer from 1990 to 2023 and forecasts to 2050: a systematic analysis for the Global Burden of Disease Study 2023”
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João Conde & GBD Collaborators - Global Burden of Disease (GBD) Consortium
230. “A hybrid large language model framework for multi-disease risk stratification and earlyclinical triage from routine blood counts”
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C. Yin, Z. Wang, F. Zhao, B. Yang, H. Zhou, C. Li, G. Fan, Y. He, B. Song, Z. Sun, H. Wang, J. Kuang, Manimurugan S., A.K. Barui, J. Zhao*, Y. Zhou*, D Xin*, P. Han*, João Conde* and S. Lou*
229. “Mapping trends in extended routine childhood vaccination in 101 countries”
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João Conde & GBD Collaborators - Global Burden of Disease (GBD) Consortium
228. “Atomically defined heteronuclear diatomic sites in porous Janus MOF enable multi enzyme nanozyme catalysis for tumour therapy”
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M. Jiang, H. Huang, M. Tan, J. Deng, Z. Huang, C. Ma, P. Ma, Y. Ye, Y. Su, S. Liang, Y. Zhao, C. Li, Z. Wu, Q. Zhang, G. Feng, Q. Jia, Y. Li, Z. Liu, A. Liu, R. Wei, T. Wang, R. Alarcón Rodríguez, Z. Bo, J. Zhao, Y. Tian, M. Ashrafizadeh, João Conde, K. Fan, R. Liang, J. Zhong and L. Zheng
227. “Targeting EP2 overcomes osimertinib resistance through metabolic and inflammatory reprogramming in non-small cell lung cancer”
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H. Yu, J. Pan, J. Wei, Y. Wu, Z. Wang, Q. Chen, M. Ashrafizadeh, João Conde*, Y. Sun*, Y. Pan* and X. Qian*
226. “Global, regional, and national prevalence of second-hand smoke and attributable disease burden in 204 countries and territories, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023”
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João Conde & GBD Collaborators - Global Burden of Disease (GBD) Consortium
225. “In situ-forming hydrogel for spatiotemporally controlled delivery of homologous cancer cell membrane-coated micelles toward metastatic pancreatic cancer therapy”
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Diana Peixoto, Catarina F. Martins, P. Diaz-Rodriguez, F. Veiga, A. Concheiro, A.C. Paiva-Santos, C. Alvarez-Lorenzo* and João Conde*
224. “CD52 is a clinically relevant regulator of tumor-immune interactions in lymph node metastasis”
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Y. Xi, L. Li, C. Xu, F. Zhao, F. Ye, M. Yuan, C. Ye, L. Jiang, Y. Huang, J. Zhang, W. Shen, J. Kuang, A.K. Barui, M. Shanmuganathan, Y. Zhou*, H. Chen*, João Conde* and B. Yu*
223. “3D bioprinted endometriosis model with fibrin bioinks for nanoparticle-Photo-Thermal Therapy evaluation”
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Cristina Volpini, G. Guagliano, N. Bloise, Barbara B. Mendes, F.B. Vangosa, P. Petrini, B. Gardella, S. Ferrero, João Conde, P. Minzioni and L. Visai*
222. “Imaging-guided NIR-II theranostic nanoprobes disable m6A reader-stabilized resistance mRNAs in pancreatic cancer”
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J. Zhu, X. Wang, Y. Xu, S. Fang, K. Zhao, Z. Yu, X. Xu, J. Zhang, M. Zhang, B. Gan, J. Lu, R. Zhou, Y. Chen, J. Sun, João Conde* and S. Zheng*
221. “Global, regional and national burden of cervical cancer and associated risk factors from 1990 to 2023 and forecasts to 2050: A systematic analysis for the Global Burden of Disease Study 2023”
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João Conde & GBD Collaborators - Global Burden of Disease (GBD) Consortium
220. “Machine learning prediction of phenotypic toxicity to liposomal formulations via pre-dose metabolomics”
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M. Zhao, , Y. Wang, Y. Xiao, G. Hu, Y. Zou, J. Li, L. Zhao, X. Ye, H. Liu, João Conde*, Y. Zhao* C. Yin* and H. Meng*
219. “Mapping COPD burdens across countries and subnations,1990-2023, and forecasts with scenarios simulation”
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João Conde & GBD Collaborators - Global Burden of Disease (GBD) Consortium
218. “Preclinical validation of a therapeutic nose-to-brain delivery for gliomas using a mucoadhesive thermoresponsive lipid nanoparticle hydrogel”
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Leonardo D. Di Filippo, J.L. Duarte, Bárbara B. Mendes, Jhenifer Oliveira, Catarina F. Martins, Mariana F. Pereira, G.A. de Paula, T.C. Ribeiro, F.F. Haddad, I.D. Figueiredo, R.M. Sábio, B.S. Rosa, G. Morais-Silva, M. Thiele, C.C. Crestani, R.L. Nunes-de-Souza, E. Sasso-Cerri, M. Chorilli* and João Conde*
217. “Rinse-triggered thermoresponsive polymer coatings for on-demand biofilm shedding and tissue integration on dental implants in multiple in vivo mammalian and human models”
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S. Ye, M. Zhang, Z. Wu, K. Zou, Q. Yu, R. Zhong, W. Huang, T. Yang*, João Conde*, W. Li* and L. Wang*
216. “Materials-guided gene-ionizable lipid nanoparticles to reverse iron-associated immune resistance in renal cancer”
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X. Jin, Y. Hong, C. Yin, W. Guo, Y. Wang, R. Zeng, R. Liu, Z. Ding, X. Liu, S. Ren, Q. Liang, Y. Wang, X. Zhang, João Conde*, Y. Li*, X. Ma* and L. Gu*
215. “Measuring the composition and availability of human resources for health by sex in 204 countries, 1990–2023, and workforce gaps for universal health coverage”
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João Conde & GBD Collaborators - Global Burden of Disease (GBD) Consortium
214. “Injectable heterojunction nanozyme-doped thermoresponsive hydrogel for synergistic ROS scavenging and microenvironment remodeling in osteoarthritis cartilage regeneration”
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K. Zhang, M. Jiang, G. Lai, M. Li, C. Lei, Q. Liao, Z. Wang, Y. Tian, T. Wang, S. Wu, C. Yang, Hu. Zhao, J. He, L. Lu, J. Meng, Z. Lin, X. Gan, Y. Liu, Z. Yuan, W.S. Toh, J.HP. Hui, X. Zheng, Z. Wang, M. Ashrafizadeh, João Conde*, Z. Bo*, Z. Wang*, S. Lu* and R. Wei*
213. “Patient-derived proteostatic-metabolic tripartite signaling nanocircuit dismantles in vivo tumor-stroma lipid symbiosis in pancreatic cancer”
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J. Zhu, C. Huang, X. Wang, J. Zhang, S. Fang, K. Zhao, Z. Yu, Y. Xu, M. Zhang, B. Gan, J. Lu, R. Zhou, Y. Chen, B. Zhang, X. Ren, J. Sun, João Conde* and S. Zheng*
212. “Global trends in maternal, neonatal infections and sepsis, 1990–2021: a systematic analysis”
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X. Tan, Y. Feng, J. Hu, K. Sun, Y. Fu, Z. Zhang, M. Ashrafizadeh, João Conde*, A. Zhang*, D. Ma* and C. Duan*
211. “Nanoparticle-mediated photothermal therapy for Acne vulgaris: recent clinical advances and AI integration”
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P. Manivasagan, A. Joe, H-W. Han, T. Thambi, Y.J. Jeon, Y-R. Lim, J. Choi, João Conde* and E-S. Jang*
210. “ZDHHC16-mediated S-palmitoylation of WDR4 enhances m7G modification and EGFR translation to facilitate liver cancer progression and lenvatinib resistance”
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Y. Chen, Q. Dai, H. Wang, J. Zhang, B. Li, S. Li, Y. Tian, M. Ashrafizadeh, João Conde*, Z. You* and L. Jiang*
209. “A self-replicating mRNA vaccine targeting p53 mutants elicits potent anti-tumor immunity against pancreatic cancer”
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C. Chen, C. Huang, Y. Wu, Z. Hou, F. Liang, J. Lin, P. You, S. Lin, Y. Zhang, H. Zhang, H. Huang*, João Conde*, M. Pan* and Y. Pan*
208. “Clinically relevant glycolytic reprogramming by ALDOA fuels immunosuppressive macrophages and pancreatic tumor growth”
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J. Lin, M. Tian, Z. Hou, C. Chen, Y. Wu, F. Liang, L. Wu, P. You, Y. Mao, Z. Zhao, J. Kuang, X. Meng, Y. Zhou, W. Jia, H. Huang*, João Conde*, P. Zhao* and Y. Pan*
207. “Global, Regional and National Distributions and Temporal Trends of Lung Cancer Burden Attributable to Residential Radon, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021”
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João Conde & GBD Collaborators - Global Burden of Disease (GBD) Consortium
206. “BRPF1 is an epigenetic checkpoint for β-catenin and NF-κB to drive immune suppression”
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Y. Hou, F. Ma, F. Meng, Z. Yang, Z. Wang, Y. Tian, ... , G. Sethi, D. Yin, R. Song, A.R. Aref, C. Nicot, M. Ashrafizadeh, João Conde*, J. Wang*, C. Zhang* and L. Liu*
205. “Spatiotemporal Distributions and Regional Disparities of Chronic Myeloid Leukemia in 953 Global to Subnational Locations, 1980–2021”
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João Conde & GBD Collaborators - Global Burden of Disease (GBD) Consortium
204. “Au-Phoenix: neutrophil-based gold-nanopeptide modules for mitochondrial rebirth via restoring EVs clearance and blocking mitophagy”
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R. Song, Y. Ma, K. Sun, F. Liang, Q. Zeng, Y. Liao, Y. Xiao, Y. Liao, X. Tan, J. Tan, M. Ashrafizadeh, João Conde*, J. Zhu* and C. Duan*
203. “Agentic AI systems for the next generation of Brain-Computer Interfaces”
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C. Liu, X. Zhou, J. Mao, Y. Ding, Q. Li, Z. Sun, J. Fang, G. Zhang, H. Wu, Y. Jin, Z. Jia, Y. Liu, H. Li, M. Qiu, D. Mandic, W. Jin, S. Luo, H. Liu, L. Deng, K. Wang, João Conde and Q. Wen
202. “TRIM14 is a key factor in the type I IFN and mitochondrial axis”
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B. Huang, H. Li, C. Jin, W. Jin, Z. Chen, Z. Tai, Q. Jiang, Y. Liu, D. Gao, L. Yang, Y-L. Lau, X. Wang, João Conde*, J. Li* and F. Yang*
201. “Deep learning forecasts reveal widening global inequalities in global-to-local childhood and adolescent cancer burden”
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João Conde & GBD Collaborators - Global Burden of Disease (GBD) Consortium
200. “COL4A2 expressing huMSCs reprogrammed CD44 function conteracting osteoblastic disulfidptosis for stem cell based therapeutics of osteonecrosis of the femoral head”
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W. Jin, Y. Zhong, Y. Zhou, João Conde*, H. Peng*, Y. Zhang* and M. Gao*
199. “Targeting the USP46/BRPF3/E2F1 epigenetic axis with PG490 overrides Lenvatinib resistance in hepatocellular carcinoma”
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Y. Zhang, F. Ma, L. Guo, Z. Wang, P. Jaydeepsinh, C. Qi, Y. Wang, C. Yang, H. Liu, D. Wang, X. Zhang, C. Jing, X. Wang, Z. Zhang, Y. Hou, M. Ashrafizade, João Conde*, Z. Ma*, W. Guo* and Z. Zhu*
198. “Multiregulatory supramolecular hydrogel nanocores reprogram cartilage homeostasis in osteoarthritis”
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R. Zhang, Y. Ma, S. Han, Z. Zhuang, C. Xu, J. Conde*, J. Li*, Q. Zhai* and C. Chen*
197. “Real-world detection and preoperative risk stratification of gallbladder cancer from routine non-contrast CT using multimodal deep learning”
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Y. Xia, J. Zhang, H. Liu, S. Mao, Q. Li, X. Wu, R. Zhong, A. Tong, C. Yang, Z. Liu, N. Xu, Z. Yan, T. Liu, S. Lu, F. Liu, J. Wang, Z. Li, J. Wang, J. Gu, Z. Zhang, J. Jia, H. Zang, K. Zhang, Z. Zhou, Y. Zhou, Y. Hong, J. Yang, J. Liu, Y. Zhou*, D. Wang*, Y. Lu*, João Conde*, Y. Liu* and M. Li*
196. “Targeted delivery of selective BET inhibitors”
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R. Traquete, E. Henderson, C. Tang, S. Picaud, T. Fujisawa, A. Guerreiro, João Conde, V. J. Tyrell, D. O. Costa, T. Rodrigues, M. C. Marques, J. D. Seixas, P. M. S. D. Cal, P. Faísca, T. Carvalho, P. Ruivo, N. Linteau, J. Bonet-Aleta, R. Wilson, P. M. P. Góis, F. Corzana, V. O’Donnell, A. Takahashi, H. Ichijo, J.-P. Lamber, A. Koehler, C. R. Goding, P. Filippakopoulos* & G. J. L. Bernardes*
195. “A multi-omics-driven diagnostic-prognostic model for precision immunotherapy of tumor-associated macrophages by reversing chemoresistance in colorectal cancer”
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Y. Sun, K. Peng, Y. Li, D. Zheng, K. Yu, C. Xu, F. Zhao, Y. Zhou, J. Kuang, Z. Li*, João Conde*, C. Ying*, W. Wang* and W. Xiao*
194. “In vivo multimodal self-immolative prodrug nanomicelles modulate key intratumoral and metastatic genomic signalling pathways in pancreatic cancer”
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João M.J.M. Ravasco, Jhenifer Oliveira, João Conniot, Bárbara B. Mendes, C. Leal, S.N. Fernandes, C.A.M. Afonso and João Conde*
193. “H₂S donor-pretreated vascular endothelial cell-derived extracellular vesicles for multi-pathway vascular repair”
Matter (2026) - IF17.5 (just accepted)
B. Gao, J. Sun, P. Wei, Y. Zhang, Y. Tian, Y. Lin, M. Ashrafizadeh, D. Kang*, João Conde* and X. Niu*
192. “Procyanidin C1 activates Nrf2/HO-1 to preserve in vivo mitochondrial homeostasis and counter chondrocyte senescence in osteoarthritis”
Cell Death & Disease (2026) - IF9.6 (just accepted)
Y. Zhang, M. Chen, W. Cai, Y. Zhou, J. Kuang, Y. Zhong, S. Wei, H. Xing, J. Zhou*, João Conde*, Y. Zhou*, H. Peng* and W. Jin*
191. “Mitochondrial Flagella-like Extensions (MitoFLARE) dysfunction triggers STING-mediated immune dysregulation in sepsis”
Nature Communications (2026) - IF15.7 (just accepted)
W. Hong, R. Ma, S. Long, R. Song, S. Ren, X. Ran, J. Wan, Y. Liu, X. Li, Q. Chen, D. Ma, Z. Zhang, H. Huang, M. Ashrafizadeh, João Conde*, L. Liu* and C. Duan*
190. “Clinical Large Language Model Centered On Electronic Medical Records”
npj Digital Medicine (2026) - IF15.1 (just accepted)
Y. Zhuang, B. Wang, C. Yin, J. Zhang, F. Meng, J. Zhao, Q. Su, X. Zhao, X. Li, P. Hu, Wurilige, Y. Hua, W. Dong, B. Wei, L. Zheng, João Conde*, G. Shi*, C. Feng* and K. He*
189. “Wearable near-infrared LED photothermal microneedle patches reduce periorbital wrinkles in a randomized pilot clinical trial”
Journal of Materials Chemistry B (2026) - IF5.8
Hyo-Won Han, D-H. Lee, A. Joe, Y.J. Jeon, Y-R. Lim, J. Choi, S.B. Lee, B-H. Bin, T. Thambi, João Conde*, P. Manivasagan* and E-S. Jang*
187. “A general strategy for site-oriented protein anchoring on metal–organic frameworks: HER2-targeted delivery using an engineered antibody fragment”
ChemRxiv (2026)
E. Siouve, F. Melle, Catarina F. Martins, C. Orozco, Jhenifer Oliveira, X. Chen, F. Demir-Duman, N. Ayaz, A. Madathil, K. Caamaño, Diana Peixoto, C. Camur, Bárbara B. Mendes, M. Bersellini, M. Carl, M. Papworth, P. Ravn, João Conde* and D. Fairen-Jimenez*
185. “Microvesicle release drive cycles of mitophagy flux disruption and inflammatory amplification in sepsis-induced myocardial dysfunction”
PNAS (2026) - IF10.6
R. Song, Y. Ma, J. Wan, S. Hao, B. Chen, Y. Liao, Y. Liao, Y. Xiao, X. Zhang, Z. Zhang, S. Ren, X. Tan, J. Tan, H. Huang, João Conde*, G. Sethi, L. Liu* and C. Duan*
180. “A predictive rheological framework to define printability of thermo-sensitive bioinks using non-temperature-controlled bioprinters”
Polymer Testing (2026) - IF6.0
I. Anjos, T. Vieira, T. Aktar, J.C. Silva, Barbara B. Mendes, João Conde, L.F Bolaños, S. Fernandes, C. Leal, J.P. Borges and D. Limón*
179. “SIRT3 deficiency impairs mitochondrial bioenergetics via hyperacetylation of TCA cycle enzymes in chronic heart failure”
Journal of Translational Medicine (2026) - IF7.5
Y. Liao, X. Tan, G. Peng, Y. Ren, R. Liu, H. Liao, Z. Luo, Z. Cao, Y. Wu, M. Ashrafizadeh, João Conde*, C. Duan*, J. Hu* and R. Ma*
175. “Smart multifunctional hydrogels with shape memory, conductivity, self-healing and adhesive properties for biomedical applications”
Materials & Design (2026) - IF7.9
H. Huong, C.H. Luu, V.H. Giang Phan, G. Janarthanan, N-T. Huynh, H.T. Nguyen, N-Y. N. Ha, H.T. Ta, S. Vijayavenkataraman*, João Conde* and T. Thambi*
174. “Global, regional, and national burden of breast cancer among females, 1990-2023, with forecasts to 2050: a systematic analysis for the Global Burden of Disease Study 2023”
The Lancet Oncology (2026) - IF35.9 - Featured on COVER
João Conde & GBD Collaborators - Global Burden of Disease (GBD) Consortium
170. “Global to local burdens, inequalities, and achievable frontiers of child and adolescent malignant neoplasm of bone and articular cartilage across 953 countries and sublocations, 1980-2040, with deep learning-based forecasts”
Journal of Orthopaedic Translation (2026) - IF7.8
João Conde & GBD Collaborators - Global Burden of Disease (GBD) Consortium
169. “Succinate Dehydrogenase B (SDHB) Overexpression with Enzymatic Dysfunction Defines a Distinct Subtype of Undifferentiated Pleomorphic Sarcoma”
Cancer Research Communications (2025) - IF3.3
M. Esperança-Martins, H. Vasques, M. Sokolov Ravasqueira, (…), C. Melo-Alvim, Isabel Fernandes, D. López-Presa, M.M. Lemos, B.A. Van Tine, A.C.S. Bastos, S. Casimiro, N. Abecasis, L. Costa, E. Gonçalves, I.F. Duarte and S. Dias
168. “Structurally and functionally optimized silk fibroin-alginate-based biomimetic scaffolds reinforced with nanobioceramics for bone tissue engineering applications”
Journal of Nanobiotechnology (2025) - IF10.6
T-M.N. Nguyen, N-H.H. Le, M. Murugesan, G. Janarthanan, P. Manivasagan, E-S. Jang, Y. Li, V.H.G. Phana, S. Vijayavenkataraman*, João Conde* and T. Thambi*
166. “Burden of 375 diseases and injuries, risk-attributable burden of 88 risk factors, and healthy life expectancy in 204 countries and territories, including 660 subnational locations, 1990–2023”
The Lancet (2025) - IF98.4 - Featured on COVER
João Conde & GBD Collaborators - Global Burden of Disease (GBD) Consortium
163. “Ibero-American Consensus for the Management of Liver Metastases of Soft Tissue Sarcoma: Updated Review and Clinical Recommendations”
Cancers (2025) - IF4.4
R. Lopes-Brás, P. Muñoz, Eduardo Netto, J.Á. Fernández, M. Serradilla-Martín, P. Lozano, M. Esperança-Martins, G. Blanco-Fernández, J.A. González-López, F.C. Muñoz-Casares, Isabel Fernandes, J.M. Asencio-Pascual and H. Vasques
161. “Transcriptomic-based classification identifies prognostic subtypes and therapeutic strategies in soft tissue sarcomas”
Cancers (2025) - IF4.4
M. Esperança-Martins, H. Vasques, M.S. Ravasqueira, M.M. Lemos, F, Fonseca, D. Coutinho, J.A. López, R.S.P. Huang, S. Dias, L. Gallego-Páez, L. Costa, N. Abecasis, E. Gonçalves and Isabel Fernandes
159. “Practical guidance on the detection of NTRK fusions in sarcomas: current status and diagnostic challenges”
Acta Médica Portuguesa (2025)
Isabel Fernandes, D. Macedo, E. Gouveia, A. Ferreira, J. Lima, D. Lopez, C. Melo-Alvim, A. Carvalho, P. Tavares, P. Rodrigues-Santos, P. Cardoso, M. Magalhães, P. Vieira, J. Brito, C. Mendes, J. Rodrigues, Eduardo Netto, V. Oliveira, C. Sousa, M.H. Abreu, F. Pina and H. Vasques
158. “Global, Regional and National Burden of Cardiovascular Diseases and Risk Factors in 204 countries and territories, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023”
Journal of the American College of Cardiology (2025) - IF22.3
João Conde & GBD Collaborators - Global Burden of Disease (GBD) Consortium
156. “A tumor microenvironment-responsive Zr-MOF nanosystem for co-delivering siHIF-1α and triptolide enhances photodynamic therapy in esophageal cancer by amplifying ROS generation and reversing hypoxia”
Materials Today Bio (2025) - IF10.2
W. Liu, C. Sun, Y. Dai, H. Wang, M. Ashrafizadeh, João Conde*, L. Yang* and W. Hea*
154. “Multiscale profiling of nanoscale metal-organic framework immune interactions”
Advanced Healthcare Materials (2025) - IF9.6
Y. Zhuang, Bárbara B. Mendes, D. Menon, Jhenifer Oliveira, X. Chen, F.D. Duman, João Conniot, S. Mercado, X. Liu, S. Zhang, J.J. Powell, João Conde*, R.E. Hewitt* and D. Fairen-Jimenez*
148. “Annexin A1 mRNA-loaded liposomes alleviate acute pancreatitis by suppressing STING pathway and promoting efferocytosis in macrophages”
Nature Nanotechnology (2025) - IF40.5
H. Fang, P. You, S. Lin, Y. Wu, J. Lin, Z. Hou, F. Liang, C. Chen, Z. Wang, L. Chen, S. Zhang, X. Chen, K. Zhao, F. Lu, M. Pan, Y. Zhou, C. Yin*, João Conde*, H. Huang* & Y. Pan*
147. “Bioengineered metastatic cancer nanovaccine with a TLR7/8 agonist for needle-free intranasal immunization”
Biomaterials (2025) - IF12.8
J.M. Jung, M.S. Lee, Y.K. Seo, J.E. Lee, S.Y. Lim, D.H. Kim, S.Y. Lyu, C. Park, B.D. Kim, J.H. Shin, J.H. Lee, P. Liu, J. Jung, João Conde, T. Thambi, J.H. Jeong and D.S. Lee
146. “Zn-DHM nanozymes enhance muscle regeneration through ROS scavenging and macrophage polarization in volumetric muscle loss revealed by single-cell profiling”
Advanced Functional Materials (2025) - IF18.5
X. Feng, Z. Luo, W. Zhang, R. Wan, Y. Chen, F. Li, Y. He, Z. Lin, J.H. Hui, Y. Li, João Conde*, S. Chen*, Z. Zhao*, X. Wang*
145. “Longan-inspired chitosan-pectin core-shell hydrogel beads for oral delivery of biodrugs to enhance osteoporosis therapy”
International Journal of Biological Macromolecules (2025) - IF7.7
V.H.G. Phan, B-P. T. Nguyen, N.Y. Nguyen, C-N. D. Tran, Q-N. D. Nguyen, C.H. Luu, P. Manivasagan, E-S Jang, D.C. Yang, D.U. Yang, Y. Li* João Conde * and T. Thambi*
144. “Age-associated reduction in ER-Mitochondrial contacts impairs mitochondrial lipid metabolism and autophagosome formation in the heart”
Cell Death & Differentiation (2025) - IF13.7
W. Hong, X. Zeng, R. Ma, Y. Tian, H. Miu, X. Ran, R. Song, Z. Luo, D. Ju, D. Ma, M. Ashrafizadeh, S.K. Bhutia, João Conde, G. Sethi*, H. Huang* and C. Duan*
139. “Rational design of Metal-Organic Frameworks for pancreatic cancer therapy: from machine learning screening to in vivo efficacy”
Advanced Materials (2025) - IF27.4 - Special issue 30 Years Reticular Materials - Featured on COVER
F. Melle, D. Menon, João Conniot, J. Ostolaza-Paraiso, X. Chen, S. Mercado, Jhenifer Oliveira, Bárbara B. Mendes, João Conde* and D. Fairen-Jimenez*
138. “Exploring the link between low germline mutational load and low breast cancer incidence: lessons from the Xavante Indians”
Translational Oncology (2025) - IF4.5
José Rueff*, João Conde* and Guilherme Castro*
† In the memory of our dear Professor José Rueff, an exceptional friend and mentor. Com amizade e carinho Professor
137. “Long-term cell-membrane coated ultrabright polymeric nano-dots for targeted cancer cell imaging and hydrophobic drug delivery”
Chemistry of Materials (2025) - IF7.2 - Polymer-Drug Conjugate Materials - Featured on COVER
Rajendra Prasad*, N. Gupta, A.S. Meena, V.G.S.S. Jyothi, A. Chan-dak and João Conde*
136. “Engineered biomimetic cisplatin-polyphenol nanocomplex for chemo-immunotherapy of glioblastoma by inducing pyroptosis”
Journal of Nanobiotechnology (2025) - IF10.6
X. Hao, Y. Tang, W. Xu, M. Wang, J. Liu, Y. Li, J. He, Y. Peng, P. Sun, D. Liao, X. Hu, T. Tang, M. Zhou, R. Han, J. Wang, João Conde*, D. Xiang* and J. Wu*
135. “Voices of Nanomedicine: blueprint guidelines for collaboration in addressing global unmet medical needs”
ACS Nano (2025) - IF15.8 - Featured on COVER
R. Prasad*, A. Ghosh, V. Patel, B. Peng, Bárbara B. Mendes, E.H.A. Win, L.G. Delogu, J.Y. Wong, K.J. Pische, J. Bellare, A. Bar-Shir, A.S. Thakor, W.J. Parak, Z.M. Bhujwalla, Y.S. Zhang, N. Kommineni, V. Rotello, W. Cai, T. Lammers, T.W. Odom, G. Padmanaban, D. Peer, J.F. Lovell, R. Srivastava*, R. Langer and João Conde*
130. “Forecasting the impacts of smoking prevalence scenarios on years of life lost and life expectancy from 2022 to 2050 - a systematic analysis for the Global Burden of Disease Study 2021”
The Lancet Public Health (2024) - IF25.4
João Conde & GBD Collaborators - Global Burden of Disease (GBD) Consortium
129. “Triterpenoid saponin-based supramolecular host-guest injectable hydrogels inhibit the growth of melanoma via ROS-mediated apoptosis”
Materials Science and Engineering: R: Reports (2024) - IF31.6
R. Mathiyalagan, M. Murugesan, Z.M. Ramadhania, J. Nahar, P. Manivasagan, E-S. Jang, D.C. Yang,
João Conde* and T. Thambi*
123. “Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021”
The Lancet (2024) - Featured on COVER - IF168.9
João Conde & GBD Collaborators - Global Burden of Disease (GBD) Consortium
122. “Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 countries and territories and 811 subnational locations, 1990–2021”
The Lancet (2024) - Featured on COVER - IF168.9
João Conde & GBD Collaborators - Global Burden of Disease (GBD) Consortium
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118. “Preclinical assessment of an antibiotic-free cationic surfactant-based hydrogel for sexually and perinatal transmitted infections”
Matter, Cell Press (2024) - IF20.0
R.D.A. Calado, Bárbara B. Mendes, João Conniot, João M.J.M. Ravasco, D. Sobral, C. Ferreira, R. Ferreira, J.C. Rodrigues, D. Santos, S. Duarte, L. Vieira, A.S. Inácio, H. Carrêlo, W.L.C. Vaz, J.P. Gomes, A. Nunes*, João Conde* and O.V. Vieira*
116. “Engineered nanomaterials for glioblastoma nanovaccination”
Nature Reviews Materials (2024) - Featured on COVER - IF86.2
F. Haamedat, Bárbara B. Mendes, João Conniot, L.D. Di Filippo, M. Chorilli, A. Schroeder, João Conde* and F. Sousa*
113. “Global age-sex-specific mortality, life expectancy, and population estimates in 204 countries and territories and 811 subnational locations, 1950–2021, and the impact of the COVID-19 pandemic”
The Lancet (2024) - Featured on COVER - IF168.9
João Conde & GBD Collaborators - Global Burden of Disease (GBD) Consortium
109. “A Fluorinated BODIPY-Based Zirconium Metal-Organic Framework for in vivo Enhanced Photodynamic Therapy”
Journal American Chemical Society (2024) - IF16.4
X. Chen, Bárbara B. Mendes, Y. Zhuang, João Conniot, S.M. Argandona, F. Melle, Diana P. Sousa, D. Perl, A. Chivu, H. K. Patra, W. Shepard, João Conde* and D. Fairen-Jimenez*
104. “Intratumoural Delivery of mRNA Loaded on a Cationic Hyper-Branched Cyclodextrin-Based Polymer Induced an Anti-Tumour Immunological Response in Melanoma”
Cancers (2023) - IF6.6
F. Trotta, M. Mahmoudian, P. Zakeri-Milani, C. Cecone, K.J. Ishii, T. Hayashi, João Conde, A. Matencio and Y.K. Monfared
99. “Bioengineered exosome membrane camouflaged-abiotic nanocarriers: neurodegenerative diseases, tissue engineering and regenerative medicine”
Military Medical Research (2023) - IF34.9
D. Lopes, J. Lopes, M. Pereira-Silva, Diana Peixoto, N. Rabiee, F. Veiga, O. Moradi, Z.H. Guo, X.D. Wang, João Conde, P. Makvandi and A.C. Paiva-Santos
95. “Exosome Membrane-Coated Nanosystems: Exploring Biomedical Applications in Cancer Diagnosis and Therapy”
Matter, Cell Press (2023) - IF20.0
M. Shao, D. Lopes, J. Lopes, S. Yousefias, A. Macário-Soares, Diana Peixoto, I. Ferreira-Faria, F. Veiga, João Conde, Y. Huang, X. Chen, A.C. Paiva-Santos and P. Makvandi
92. “Magnetite and bismuth sulfide Janus heterostructures as radiosensitizers for in vivo enhanced radiotherapy in breast cancer”
Biomaterials Advances (2022) - IF8.4
H. Nosrati, M. Ghaffarlou, M. Salehiabar, N. Mousazadeh,F. Abhari, M. Barsbay, Y.N. Ertas, H. Rashidzadeh, A. Mohammadi, L. Nasehi, H. Rezaeejam, S. Davaran, A. Ramazani*, João Conde* and H.
Danafar*
87. “Global, regional, and national burden of colorectal cancer and its risk factors, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019”
The Lancet Gastroenterology & Hepatology (2022) - IF45.0
João Conde & GBD 2019 Colorectal Cancer Collaborators - Global Burden of Disease (GBD) Consortium
86. “PrimeView - Nanodelivery of nucleic acids”
Nature Reviews Methods Primers (2022) - IF50.1
Highlighted in the "Nobel Prize in Physiology or Medicine 2023" Collection
Bárbara B. Mendes, João Conniot, A. Avital, D. Yao, X. Jiang, X. Zhou, N. Sharf-Pauker, Y. Xiao, O. Adir, H. Liang*, J. Shi*, A. Schroeder* and João Conde*
86. “Nanodelivery of nucleic acids”
Nature Reviews Methods Primers (2022) - IF50.1
Highlighted in the "Nobel Prize in Physiology or Medicine 2023" Collection
Bárbara B. Mendes, João Conniot, A. Avital, D. Yao, X. Jiang, X. Zhou, N. Sharf-Pauker, Y. Xiao, O. Adir, H. Liang*, J. Shi*, A. Schroeder* and João Conde*
85. “Burden of non-communicable diseases among adolescents aged 10–24 years in the EU, 1990–2019: a systematic analysis of the Global Burden of Diseases Study 2019”
The Lancet Child & Adolescent Health (2022) - Featured on Cover - IF37.7
João Conde & GBD 2019 Collaborators - Global Burden of Disease (GBD) Consortium
83. “The global burden of adolescent and young adult cancer in 2019: a systematic analysis for the Global Burden of Disease Study 2019”
The Lancet Oncology (2021) - Featured on COVER - IF54.4
João Conde & GBD 2019 Adolescent and Young Adult Cancer Collaborators - Global Burden of Disease (GBD) Consortium
82. “Prodrug polymeric nanoconjugates encapsulating gold nanoparticles for enhanced X-Ray radiation therapy in breast cancer”
Advanced Healthcare Materials (2021) - Rising Star Issue - Featured on COVER - IF11.1
H. Nosrati, F. Seidi, A. Hosseinmirzaei, N. Mousazadeh, A. Mohammadi, Mo. Ghaffarlou, H. Danafar, João Conde* and Ali Sharafi*
80. “Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019: A Systematic Analysis for the Global Burden of Disease Study 2019”
JAMA Oncology (2021) - IF33.0
João Conde & GBD 2019 Cancer Collaborators - Global Burden of Disease (GBD) Consortium
77. “Global, regional, and national progress toward Sustainable Development Goal 3.2 for neonatal and child health: all-cause and cause-specific mortality findings from the Global Burden of Disease Study 2019”
The Lancet (2021) Featured on COVER - IF202.7
João Conde & GBD 2019 Under-5 Mortality Collaborators - Global Burden of Disease (GBD) Consortium
75. “Allosteric Antagonist Modulation of TRPV2 by Piperlongumine Impairs Glioblastoma Progression”
ACS Central Science (2021) Featured on COVER - IF18.7
João Conde, R.A. Pumroy, C. Baker, T. Rodrigues, (...), F. Corzana, V.A. Morais, C.C. Faria, T. Carvalho, P. Filippakopoulos, B. Snijder, N.L. Barbosa-Morais, V.Y. Moiseenkova-Bell, G.J.L. Bernardes
73. “Ultrahigh penetration and retention of graphene quantum dot mesoporous silica nanohybrids for image guided tumor regression”
ACS Applied Bio Materials (2021) Featured on COVER - IF3.3
R. Prasad*, N.K. Jain, A.S. Yadav, M. Jadhav, N.N.V. Radharani, M. Gorain, G.C. Kundu, João Conde*, R. Srivastava*
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64. “Platinum-triggered Bond-cleavage of Pentynoyl amide and N-propargyl handles for Drug-Activation”
Journal American Chemical Society (2020) Featured on COVER - IF16.4
B.L. Oliveira, B.J. Stenton, Unnikrishnan V.B., C.R. Almeida, João Conde, M. Negrão, F.S.S. Schneider, C. Cordeiro, M.G. Ferreira, G.F. Caramori, J.B Domingos, R. Fior and G.J.L. Bernardes
63. “Stepwise Assembly of Multimode Liposomal Nanotheranostic Agent for Targeted In Vivo Bioimaging and NIR Light Mediated Cancer Therapy”
Communications Biology (2020) - IF6.5
R. Prasad, N.K. Jain, A.S. Yadav, D.S. Chauhan, J. Devrukhkar, M.K. Kumawat, S. Shinde, M. Gorain, A.S. Thakor, G.C. Kundu, João Conde*, R. Srivastava*
60. “Allosteric Antagonist Modulation of TRPV2 by Piperlongumine Impairs Glioblastoma Progression”
Cell Sneak Peek (2019) - IF41.6
C. Baker*, T. Rodrigues*, R.A. Pumroy*, João Conde*, D. Picard, M.C. Marques, B.P. de Almeida, A. Samanta, F. Sieglitz, M. Langini, M. Remke, R. Roque, F. Corzana, C.C. Faria, T. Carvalho, N.L. Barbosa-Morais, V.Y. Moiseenkova-Bell, G.J.L. Bernardes
58. “Oral pH sensitive GNS@ab Nanoprobes for targeted therapy of Helicobacter Pylori without disturbance gut microbiome”
Nanomedicine: Nanotechnology, Biology and Medicine (2019) - IF6.5
X. Zhi, Y. Liu, L. Lin, M. Yang, L. Zhang, L. Zhang, Y. Liu, G. Alfranca, L. Ma, Q. Zhang, H. Fu, João Conde, X. Di, J. Ni, J. Song, D. Cui
57. “Gastric parietal cell and Intestinal goblet cell secretion: a novel cell-mediated in vivo nanoparticle clearance pathway enhanced with diarrhea via Chinese Herbs”
Nanoscale Research Letters (2019) - IF5.4
Y. Liu, K. Liu, M. Yang, Y. Han, Q. Zhang, João Conde, Y. Yang, Y. Han, G. Alfranca, Y. Wang, J. Song, Y. Zhang, J. Ni, J.M. de la Fuente, D. Cui
33. “Significance of the balance between intracellular glutathione and polyethylene glycol for successful release of small interfering RNA from gold nanoparticles”
Nano Research (2015) - IF10.3
M. McCully, Y. Hernandez, João Conde, P.V. Baptista, J.M. de la Fuente, A. Hursthouse, D. Stirling and C.C.Berry
30. “Dual targeted immunotherapy via in vivo delivery of biohybrid RNAi-peptide nanoparticles to tumour-associated macrophages and cancer cells”
Advanced Functional Materials (2015). Featured on COVER - IF19.9
João Conde*, C. Bao, Y. Tan, D. Cui, E.R. Edelman, H.S. Azevedo, H.J. Byrne, N. Artzi and F. Tian*
9. “Genotoxic effects of occupational exposure to lead and influence of polymorphisms in genes involved in lead toxicokinetics and in DNA repair”
Environment International (2012) - IF13.3
J. García-Lestón, J. Roma-Torres, M. Vilares, R.Pinto, J. Prista, J.P. Teixeira, O. Mayan, João Conde, M. Pingarilho, J.F. Gaspar, E. Pásaro, J. Méndez and B. Laffon
